Exosomes in Regenerative Medicine
Exosomes are membrane-enclosed entities that are released into the extracellular milieu and correlate with normal physiologic processes. Their modulation of these processes suggests that they directly contribute to communication between cellular components and impact healing of many disease states.
What are exosomes and what can they do?
Since the original description of exosomes over 30 years ago, the term has been loosely used for various forms of extracellular vesicle, muddying the field and contributing to the scepticism with which the research has sometimes been met. Exosomes are best defined as extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment, the multivesicular body (MVB), with the plasma membrane. This liberates intraluminal vesicles (ILVs) into the extracellular milieu and the vesicles thereby released are what we know as exosomes
Exosomes have been explored as a means of treatment when applied to regenerative therapy as their ability to store molecular structures and communicate with other cells helps contribute to healing. Since exosomes that are secreted from fibrocytes contain proteins and microRNA crucial in regulating collagen deposition and treating inflammation, they have been attributed to improving tissue health during wound therapy.
The use of exosomes in skin repair and wound healing
Exosomes or extracellular vesicles are utilized because of their excellent therapeutic potential. Improved vascularization, control of inflammation, the rejuvenation of skin from the effects of aging or trauma are some of the benefits that can be derived from the use of exosomes.
Exosomes have shown in many studies to have positive effects on both wound healing and skin repair making them attractive treatment options in regenerative medicine and in the treatment of acute and chronic wounds. In one study, exosomes were shown to have tremendous potential as a noncellular, off-the-shelf therapeutic modality for wound healing.
These peer-reviewed scientific articles all demonstrate the
amazing benefits of using exosomes in regenerative medicine.
Vesicles that transport proteins, lipids, nucleic acids, DNA, and RNA species throughout body fluids such as blood, urine, and cell cultures
Naturally occurring, contains high molecular weight of Hyaluronic Acid, contains Collagen types I & III which provide structural skin support
Contains growth factors NGF, SCF and VEGF for wound healing, growth and repair of skin; cartilage growth, repair and healing
- Product rich in Collagen, Hyaluronic Acid, regenerative cell growth factors/proteins and complex amino acids
High volume of Chondroitin Sulfate
- Regenerative Cell Factor – transmembrane soluble protein that aids in activating your own regenerative cells which aids in wound healing
Nerve Growth Factor- a polypeptide that in addition to its effects on nerve cells, it plays a role in tissue repair and that it can accelerate wound healing
Vascular Growth Factor – involved in signaling to restore oxygen supply to tissues
Regulate signaling, coagulation and waste management in the human body
Assist the body’s natural healing process by transporting cells and molecules essential for treating injuries
Can help repair wounds, bone fractures and inflamed or damaged tissue
|Collagen I, III||1.643 mg/ml|
|Hyaluronic Acid (HA)||1.85 ug/ml|
|Chondroitin Sulfate (CS)||1.58 ug/ml|
|Regenerative Cell Factor (SCF)||38.0 pg/ml|
|Vascular Endothelial Growth Factor (VEGF)||1.8 ng/ml|
Lipids, proteins and nucleic acids are transported to MVBs and onto or into the intraluminal vesicles, which upon fusion of the MVB with the plasma membrane are released as exosomes.
Clinical Studies on the Capabilities of Exosomes
There are more than 200,000 peer reviewed scientific publications on pubmed and other medical journals with thousands discussing positive outcomes following the use of exosomes in regenerative medicine.