Exosomes in Regenerative Medicine

Exosomes are membrane-enclosed entities that are released into the extracellular milieu and correlate with normal physiologic processes. Their modulation of these processes suggests that they directly contribute to communication between cellular components and impact healing of many disease states.

Exosomes

What are exosomes and what can they do?

Since the original description of exosomes over 30 years ago, the term has been loosely used for various forms of extracellular vesicle, muddying the field and contributing to the scepticism with which the research has sometimes been met. Exosomes are best defined as extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment, the multivesicular body (MVB), with the plasma membrane. This liberates intraluminal vesicles (ILVs) into the extracellular milieu and the vesicles thereby released are what we know as exosomes

Exosomes have been explored as a means of treatment when applied to regenerative therapy as their ability to store molecular structures and communicate with other cells helps contribute to healing. Since exosomes that are secreted from fibrocytes contain proteins and microRNA crucial in regulating collagen deposition and treating inflammation, they have been attributed to improving tissue health during wound therapy.

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The use of exosomes in skin repair and wound healing

Exosomes or extracellular vesicles are utilized because of their excellent therapeutic potential. Improved vascularization, control of inflammation, the rejuvenation of skin from the effects of aging or trauma are some of the benefits that can be derived from the use of exosomes.

Exosomes have shown in many studies to have positive effects on both wound healing and skin repair making them attractive treatment options in regenerative medicine and in the treatment of acute and chronic wounds.  In one study, exosomes were shown to have tremendous potential as a noncellular, off-the-shelf therapeutic modality for wound healing.

These peer-reviewed scientific articles all demonstrate the
amazing benefits of using exosomes in regenerative medicine.

Exosomes characteristics

  • Vesicles that transport proteins, lipids, nucleic acids, DNA, and RNA species throughout body fluids such as blood, urine, and cell cultures

  • Naturally occurring, contains high molecular weight of Hyaluronic Acid, contains Collagen types I & III which provide structural skin support

  • Contains growth factors NGF, SCF and VEGF for wound healing, growth and repair of skin; cartilage growth, repair and healing

  • Product rich in Collagen, Hyaluronic Acid, regenerative cell growth factors/proteins and complex amino acids
  • High volume of Chondroitin Sulfate

  • Regenerative Cell Factor – transmembrane soluble protein that aids in activating your own regenerative cells which aids in wound healing
  • Nerve Growth Factor- a polypeptide that in addition to its effects on nerve cells, it plays a role in tissue repair and that it can accelerate wound healing

  • Vascular Growth Factor – involved in signaling to restore oxygen supply to tissues

  • Regulate signaling, coagulation and waste management in the human body

  • Assist the body’s natural healing process by transporting cells and molecules essential for treating injuries

  • Can help repair wounds, bone fractures and inflamed or damaged tissue

Exosomes Ingredients

Factors Quantity
Collagen I, III 1.643 mg/ml
Hyaluronic Acid (HA) 1.85 ug/ml
Chondroitin Sulfate (CS) 1.58 ug/ml
Regenerative Cell Factor (SCF) 38.0 pg/ml
Vascular Endothelial Growth Factor (VEGF) 1.8 ng/ml
Exosomes

Lipids, proteins and nucleic acids are transported to MVBs and onto or into the intraluminal vesicles, which upon fusion of the MVB with the plasma membrane are released as exosomes.

Clinical Studies on the Capabilities of Exosomes

There are more than 200,000 peer reviewed scientific publications on pubmed and other medical journals with thousands discussing positive outcomes following the use of exosomes in regenerative medicine.

Types of Allografts we offer

Anu RHEO+

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Exosomes

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Procurement Process

All birth tissue products are obtained from C-section deliveries from normal, full-term pregnancies.  Donors that consent to use of their birth tissues are carefully screened prior to the use of their tissues in manufacturing.

Comprehensive medical and social histories of the donors are obtained and tissues are procured, processed, and tested to minimize potential risks of disease transmission to recipients. Infectious disease testing is performed at a certified laboratory in accordance with the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and 42 CFR part 493.

Each donor is tested for HBsAg  (Hepatitis  B  Surface  Antigen),  HBcAb  (hepatitis  B  core  Antibody), HCV (hepatitis C Antibody), HIV I/II-Ab (Antibody to Human Immunodeficiency Virus Types 1 and Syphilis detection test, HIV NAT (HIV Nucleic Acid Test), and HCV NAT (HCV Nucleic Acid  Test).

All products are tested post-sterilization to demonstrate the absence of bacterial and fungal pathogens and are non-pyrogenic.