Autologous Bone Marrow Aspiration

Autologous Bone Marrow Aspiration &
Bone Graft Harvesting

Autologous Bone Marrow Aspiration2018-11-08T14:44:38+00:00

Introduction to Marrow Cellution™

Benefits at a Glance

  • Less peripheral blood in the sample
  • Single acquisition site
  • 20 minute procedure
  • Low discomfort for the patient
  • Average 3000 CFU’s per ml
  • Very low host morbidity
  • Qualifies under newly released FDA Guidance criteria**

How it Works

MARROW CELLUTION™ maximizes stem & progenitor cell recovery while minimizing peripheral blood infiltration. Because fluid under force follow the path of least resistance, traditional trocar needles with side ports aspirate primarily through the distal end of the cannula. This leads to excessive blood collection, requiring additional manipulation (i.e. centrifugation or chemical separation in a laboratory).

A traditional trocar needle aspirates primarily peripheral blood.

MARROW CELLUTION™ accesses aspirate flow collected exclusively laterally as the tip of the aspiration cannula is closed, allowing marrow collection perpendicular to and around the channel created by the device. It incorporates technology to precisely reposition the harvesting cannula within the marrow space after each aspiration. These features achieve a clinicians’ desire for a single entry point.

MARROW CELLUTION™ aspirates from multiple geographies while limiting peripheral blood collection.

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Advantages to the Marrow Cellution™ System

  • Reduce the Cost of Utilizing Biologics
    The Marrow Cellution™ System delivers a regenerative solution at a reduced cost compared to the industry leading solutions.

  • Minimize O/R Time
    Centrifugation systems typically require 20 minutes or more of spin time during the surgical procedure, not to mention the additional personnel (i.e. perfusion) and support time needed for preparation and cleanup of the equipment.

  • Minimize Sterility Challenges
    Centrifugation systems require passing the BMA off the sterile field for processing and back on for implantation. The Marrow Cellution™ System eliminates the additional steps where infection concerns must be managed.

  • Minimize Sample Waste
    Centrifugation systems typically discard 80% of the aspirate due to the high levels of peripheral blood. Worse, significant numbers of the desired cells (approx. 40%) are discarded because as these cells increase in density prior to division, they are processed into the undesired red cell centrifuge component and thus discarded, substantially limiting the regenerative potential of the resulting sample.

  • Minimize Use of Anti-Coagulants
    Centrifugation systems require at least 10% dilution by volume for the addition of anti-coagulant to allow the sample to separate, and also require another 10% dilution in the form of a neutralizing agent such as thrombin and calcium chloride in order for the marrow to clot in the graft. The Marrow Cellution™ System eliminates these requirements.

  • Eliminate the Need to Filter
    Protocols require the marrow to be filtered prior to centrifugation. Cells bound within a cell aggregate can be delivered to the patient when mixed with graft material or injected. This is not the case when aggregates are filtered out prior to centrifugation. Filtering takes additional time, but more importantly, filtering reduces regenerative potential.

Benefits at a Glance

  • Less peripheral blood in the sample

  • Single acquisition site

  • 20 minute procedure

  • Low discomfort for the patient

  • Average 3000 CFU’s per ml

  • Very low host morbidity

  • Qualifies under newly released FDA Guidance criteria

Comparative analysis of marrow cellutions and emcyte® bmc system (pdf)

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Comparative analysis of marrow cellutions and the bmac® harvest®/terumo® system (pdf)

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