Key Points

Key Points2018-10-01T14:27:11+00:00

Benefits of a High Quality Allograft Versus Bone Marrow or Adipose Tissue

  • High proliferative capacity and an abundant supply of live mesenchymal stem cells

  • Trilineage differentiation ability  – ectoderm, mesoderm, and endoderm

  • Can differentiate into adipogenic, osteogenic, chondrogenic, and neural cells

  • Provokes little immune response when transplanted, cell rejection is not an issue and human leukocyte antigen (HLA) matching is not necessary

  • Immunomodulatory properties –

    • Cells do not pose risk for metastasis of tumor cells
    • Cells promote proteins that halt the cell cycle of cancer cells and promote tumor suppressing genes
    • Cells invoke the body’s immune system
  • Induce hepatocyte differentiation

  • Can differentiate into Schwann cells

  • Help organize tendon collagen fibers

  • Noninvasive procedures such as liposuction or bone marrow collection. Are more robust than other MSC from other sources such as fat. Range and level of specific cytokines that are different from those expressed by adult mesenchymal stem cells

Utilizing Wharton’s jelly for cartilage repair is a highly favorable option as it triggers little to no immune response, is minimally invasive and does not produce teratogens or carcinogens after transplantation, placing emphasis on patient safety and comfort. Cell-based cartilage repair therapy would ultimately provide first line treatment by preventing and limiting the progression of joint wear until it results in a more severe issue. With approximately 400,000 MSCs residing in Wharton’s jelly, they are easily accessible and can provide positive results without depleting quickly. MSCs sourced from Wharton’s jelly can be stored for long periods of time, allowing for off-the-shelf use that maintains viability and integrity while ensuring that the beneficial MSCs are readily available for regenerative healing.
  • Have stronger myogenic potential and engraftment properties

  • Have a stronger anti-inflammatory protective effect

  • Have less damage from reactive oxygen species (ROS)

  • Increased expression of integrin and increased phosphorylation of focal adhesion kinase Src and FAK

  • Lack the damage from NSAIDs improving the cells viability or plasticity

  • Have been shown to differentiate into nervous system cells, liver, pancreas, heart, and other organs of the body

  • Continue to express molecules with immune-modulating activity after they are extracted from    the umbilical cord and able to pass this ability to their progeny This enables the infused donor  cells, whether differentiated or not, to engraft into the diseased target organ and positively modify its microenvironment to promote repopulation the infusion of immunomodulatory MSC provide a significant advantage by better overcoming host responses, providing the needed  functional bridging action, and modifying the underlying pathological conditions at the basis of disease

  • Retain telomere at the highest possible length which protects them from premature loss of viability

  • Larger amount of different growth factors especially bFGF

  • Strong migratory ability toward the site of inflammation

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