Exosomes in Regenerative Medicine
XOGlO® is a purified mesenchymal stem cell (MSC)- derived exosome product that contains a multitude of growth factors that can enhance the coordinated cascade of cellular and biochemical events involved in natural wound healing and skin rejuvenation/regeneration.
The physiologic effects of the exosomal growth factors in XoGlo® can be used to stimulate the healing of acute and chronic wounds, regenerate collagen in aging and damaged skin, and reduce inflammation. XoGlo® has the potential to accelerate wound healing, improve skin texture, reduce scarring stimulate hair growth, and shorten recovery time after cosmetic procedures.
XoGlo® is a cell-free isolate of MSC exosomes. This concentrated biologic product is sterile – filtered and re-suspended in 10.9% normal saline. Each milliliter of XoGlo® contains 1 billion MSC exosomes.
Mesenchymal Stem Cell Exosomes
Advantages of Young Progenitor Cells
As we age, the number and function of the MSCs in our tissues declines sharply. Aged autologous progenitor cells produce about 30% of the cytokines and significantly different miRNAs compared with perinatal MSCs. This substantial difference in the secretome confers a significant advantage of perinatal MSC Exosomes over exosomes from aged autologous or allogeneic progenitor cells.
Effects of MSC Exosomes on Skin
MSC Exosomes stimulate the proliferation and migration of cells such as fibroblasts, endothelial cells, keratinocytes, and specific endogenous progenitor cells that are involved in healing damaged tissues to increase angiogenesis (new blood vessel formation), improve survival of damaged tissues, accelerate wound healing and skin regeneration, and reduce scarring.