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Exosomes in Regenerative Medicine

Exosomes are membrane-enclosed entities that are released into the extracellular milieu and correlate with normal physiologic processes. Their modulation of these processes suggests that they directly contribute to communication between cellular components and impact healing of many disease states.

Clinical Research Exosomes

Kimera Labs® manufactures sterile suspensions of isolated, neonatal, mesenchymal stem cell exosomes for IRB-approved preclinical research and development of clinical investigational study.

Knowing the therapeutic potential of MSC exosomes for autoimmune, inflammatory, degenerative, metabolic, and malignant conditions, as well as traumatic injuries, Kimera Labs® produces isolated MSC exosomes for scientific research and future academic and professional clinical research. Kimera Labs® is actively involved in preclinical research directed toward the development of exosome biopharmaceuticals for future clinical therapy.

(Sample product image is not indicative of clinical research exosome labeling)

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Exosomes are nano-scale extracellular vesicles

Very small packages of signaling information one thousandth the size of a cell. They are produced by virtually every cell type as a means of intercellular communication. This natural paracrine signaling system allows a healthy body to run like a well-oiled machine.

Exosomes contain proteins such as growth factors. enzymes, receptors, transcription factors and matrix proteins that govern cell structure, function and signaling. They also contain messenger RNA (mRNA), the blueprint for protein production, and micro RNA (miRNA), an important intracellular signaling mediator. Having the same type of membrane as their parent cells, Exosomes protect these exosomal proteins and miRNA from degradation until they are delivered to the target cell.

When Exosomes deliver their contents to target cells, exosomal proteins can have direct effects on intracellular processes and signaling. E signaling. Exosomal mRNA may be translated by the target cell to produce numerous copies of the regenerative protein. Exosomes miRNA influences target cell protein production by interfering with specific endogenous protein production. Exosomes signaling can also alter target cell exosome loading for cascading effects and a more sustained effect than the type of proteins in PRP or amniotic fluid alone could achieve.