RegenOMedix is a regenerative cell supplier and allograft product company. Our goal is to inform you about regenerative cell and allograft products as a substitute to traditional pain management and surgery. Not all the information here will apply to your individual patient’s treatment or its outcome. The information is intended to answer some of your questions about stem cells and allograft products and serve as a stimulus for you and your practice as a possible addition to your current therapies.

The Power of Stem Cells

Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the patient is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue or organ-specific cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.

In 2006, researchers made a breakthrough by identifying conditions that would allow some specialized adult cells to be “reprogrammed” genetically to assume a stem cell-like state. This new type of stem cell is called induced pluripotent stem cells (iPSC’s).

Stem cells are important for living organisms for many reasons. In the 3- to 5-day-old embryo, called a blastocyst, the inner cells give rise to the entire body of the organism, including all of the many specialized cell types and organs such as the heart, lungs, skin, sperm, eggs and other tissues. In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacements for cells that are lost through normal wear and tear, injury, or disease. Given their unique regenerative abilities, stem cells offer new potentials for treating diseases such as diabetes, and heart disease. However, much work remains to be done in the laboratory and the clinic to understand how to use these cells for cell-based therapies to treat disease, which is also referred to as regenerative or reparative medicine.

Laboratory studies of stem cells enable scientists to learn about the cells’ essential properties and what makes them different from specialized cell types. Scientists are already using stem cells in the laboratory to screen new drugs and to develop model systems to study normal growth and identify the causes of birth defects.

Research on stem cells continues to advance knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. Stem cell research is one of the most fascinating areas of contemporary biology, but, as with many expanding fields of scientific inquiry, research on stem cells raises scientific questions as rapidly as it generates new discoveries.



What is Regenerative Medicine?

Regenerative medicine uses stem cells and allograft products to offer alternative solutions to costly surgeries and offers hope for people with conditions that today are beyond repair.

Current Treatments Utilizing Regenerative Medicine

Aseptic Processing

Aseptic processing is crucial for biologic-based products as we strive to maintain the viability of the cellular components, growth factors, and protein messengers. Aseptic techniques are deployed to ensure the absence of pathogenic organisms so as to protect the patient from infection and to prevent the spread of pathogens. If during processing these cells were destroyed and the proteins denatured, they would no longer be viable and their usefulness would be negated.

In an aseptic process, the container/closure is subjected to sterilization methods separately, as appropriate, and then brought together with the biologic allograft. Because there is no process to sterilize the product in its final container, it is crucial the containers be filled and sealed under the most stringent aseptic technique possible.

The goal of aseptic processing is to minimize the risk of introducing any microbial contaminant into our product as it moves through the manufacturing process. We must be absolutely certain that there is no microbial contamination of the final sealed product. We utilize various approved techniques to ensure our allograft products are free of contaminants, thereby reducing the risk of infection to the patient.

protection against coronavirus spreading further is hand hygiene

Investigating the different types of stem cells

Embryonic Stem Cells

Embryonic stem cells are found within the blastocyst, a structure that forms within three to five days after fertilization and contains an inner mass that hosts stem cells. During prenatal development, cells inside of a blastocyst can give rise to specialized cells that work to create the tissue and organs that make up the entire body. When extracted from the blastocyst and grown under certain conditions in a laboratory, these cells retain their properties as embryonic stem cells. As pluripotent cells, they are self-renewing and capable of producing any cell type or tissue the body needs for regenerative healing. They are highly valuable because they offer a means for scientists to study cellular development and test new treatment options. The embryonic stem cells used in regenerative medicine are derived from blastocysts created through in vitro fertilization with informed consent from donors and are not taken directly from a woman’s body.

Tissue Specific Stem Cells

Tissue-specific stem cells, known as somatic or adult stem cells, are more centered around specialization as they typically generate cell types based on the tissue or organ they originate from. As an example, blood-forming, hematopoietic stem cells found in the bone marrow can produce red and white blood cells and platelets, but cannot create cells for other parts of the body such as the lung, brain or liver. Similarly, stem cells constructed for other tissues and organs will not be able to generate blood cells or platelets. Tissue-specific stem cells do not self-renew as easily and can be difficult to find in comparison to embryonic stem cells. However, studies on tissue-specific stem cells have expanded our general knowledge of human development as they give us insight on how the body grows, ages and responds to injury and illness.

Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSC’s) are engineered in labs to reprogram tissue-specific cells to operate like embryonic stem cells. While iPSC’s are designed to replicate the characteristics of embryonic stem cells such as giving rise to every cell type in the body, there are discrepancies between the two. Because iPSC’s can be designated to serve a specific function, researchers are experimenting with ways to fully convert iPSC’s into a readily available source of stem cells for regenerative therapy. They are vital in helping researchers study the development of organisms, discovering how diseases progress and providing a basis for creating and testing new medical treatments.

Mesenchymal Stem Cells

Mesenchymal stem cells (MSC’s) are stromal cells that are normally found in the bone marrow. However, MSC’s can be grown from other tissue material as well such as cord blood, peripheral blood, fetal liver, lung, and fallopian tube. Because they are multipotent stem cells, they are capable of differentiating to form cell types like adipocytes, chondrocytes, osteocytes and cardiomyocytes. Their high capacity for self-renewal gives MSC’s great potential for replacing or repairing damaged tissue such as bone, cartilage, muscle, tendons, and skin.