RegenOMedix is a regenerative cell supplier and allograft product company. Our goal is to inform you about regenerative cell and allograft products as a substitute to traditional pain management and surgery. Not all the information here will apply to your individual patient’s treatment or its outcome. The information is intended to answer some of your questions about stem cells and allograft products and serve as a stimulus for you and your practice as a possible addition to your current therapies.
The Power of Stem Cells
Stem cells have the remarkable potential to develop into many diﬀerent cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the patient is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.
Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue or organ-speciﬁc cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.
In 2006, researchers made a breakthrough by identifying conditions that would allow some specialized adult cells to be “reprogrammed” genetically to assume a stem cell-like state. This new type of stem cell is called induced pluripotent stem cells (iPSC’s).
Stem cells are important for living organisms for many reasons. In the 3- to 5-day-old embryo, called a blastocyst, the inner cells give rise to the entire body of the organism, including all of the many specialized cell types and organs such as the heart, lungs, skin, sperm, eggs and other tissues. In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacements for cells that are lost through normal wear and tear, injury, or disease. Given their unique regenerative abilities, stem cells oﬀer new potentials for treating diseases such as diabetes, and heart disease. However, much work remains to be done in the laboratory and the clinic to understand how to use these cells for cell-based therapies to treat disease, which is also referred to as regenerative or reparative medicine.
Laboratory studies of stem cells enable scientists to learn about the cells’ essential properties and what makes them diﬀerent from specialized cell types. Scientists are already using stem cells in the laboratory to screen new drugs and to develop model systems to study normal growth and identify the causes of birth defects.
Research on stem cells continues to advance knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. Stem cell research is one of the most fascinating areas of contemporary biology, but, as with many expanding ﬁelds of scientiﬁc inquiry, research on stem cells raises scientiﬁc questions as rapidly as it generates new discoveries.
What is Regenerative Medicine?
Regenerative medicine uses stem cells and allograft products to oﬀer alternative solutions to costly surgeries and oﬀers hope for people with conditions that today are beyond repair.
Current Treatments Utilizing Regenerative Medicine
Aseptic processing is crucial for biologic-based products as we strive to maintain the viability of the cellular components, growth factors, and protein messengers. Aseptic techniques are deployed to ensure the absence of pathogenic organisms so as to protect the patient from infection and to prevent the spread of pathogens. If during processing these cells were destroyed and the proteins denatured, they would no longer be viable and their usefulness would be negated.
In an aseptic process, the container/closure is subjected to sterilization methods separately, as appropriate, and then brought together with the biologic allograft. Because there is no process to sterilize the product in its final container, it is crucial the containers be filled and sealed under the most stringent aseptic technique possible.
The goal of aseptic processing is to minimize the risk of introducing any microbial contaminant into our product as it moves through the manufacturing process. We must be absolutely certain that there is no microbial contamination of the final sealed product. We utilize various approved techniques to ensure our allograft products are free of contaminants, thereby reducing the risk of infection to the patient.