Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration


  • 1ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., 08594 Seoul, Korea.
  • 2School of Chemical and Biological Engineering, Seoul National University, 08826 Seoul, Korea.
  • 3Oaro Dermatology Clinic, 13620 Seoul, Korea.
  • 4Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwasweong-si, 18450 Gyeonggi-do, Korea.
  • 5Guam Dermatology Institute, Tamuning, GU 96913, USA.
  • 6Oaro Dermatology Clinic, 01695 Seoul, Korea.
  • 7Piena Clinic, 06120 Seoul, Korea.

PMID: 32392899 – PMCID: PMC7290908 – DOI: 10.3390/cells9051157


Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo models. In addition, recent advances in the field of exosome biology have enabled development of specific guidelines and quality control methods, which will ultimately lead to clinical application of exosomes. This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.

Keywords: MSC-exosomes; anti-aging; anti-inflammation; hair growth; immunomodulation; mesenchymal stem cells (MSCs); regenerative aesthetics; skin barrier; therapeutics; wound healing.

Conflict of interest statement

Y.W.Y. and B.S.C. are founders and stockholders of ExoCoBio Inc. D.H.H., H.-k.K., J.H.L., S.S., Y.W.Y., and B.S.C. are employees of ExoCoBio Inc. Other authors declare no conflict of interest.


Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

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    1. Yi Y.W., Lee J.H., Kim S.Y., Pack C.G., Ha D.H., Park S.R., Youn J., Cho B.S. Advances in analysis of biodistribution of exosomes by molecular imaging. Int. J. Mol. Sci. 2020;21:665. doi: 10.3390/ijms21020665. – DOI – PMC – PubMed
    1. Chargaff E., West R. The biological significance of the thromboplastic protein of blood. J. Biol. Chem. 1946;166:189–197. – PubMed
    1. Johnstone R.M., Adam M., Hammond J.R., Orr L., Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes) J. Biol. Chem. 1987;262:9412–9420. – PubMed
    1. Wang Y., Wang Q., Wei X., Shao J., Zhao J., Zhang Z., Chen Z., Bai Y., Wang N., Wang Y., et al. Global scientific trends on exosome research during 2007–2016: A bibliometric analysis. Oncotarget. 2017;8:48460–48470. – PMC – PubMed
    1. Valadi H., Ekstrom K., Bossios A., Sjostrand M., Lee J.J., Lotvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007;9:654–659. doi: 10.1038/ncb1596. – DOI – PubMed